防腐劑與乳癌

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transform_skew_y=”0″ transform_scale_x_hover=”1″ transform_scale_y_hover=”1″ transform_translate_x_hover=”0″ transform_translate_y_hover=”0″ transform_rotate_hover=”0″ transform_skew_x_hover=”0″ transform_skew_y_hover=”0″ transform_origin=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” last=”true” border_position=”all” first=”true”][fusion_text columns=”” column_min_width=”” column_spacing=”” rule_style=”” rule_size=”” rule_color=”” hue=”” saturation=”” lightness=”” alpha=”” content_alignment_medium=”” content_alignment_small=”” content_alignment=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” margin_top=”” margin_right=”” margin_bottom=”” margin_left=”” fusion_font_family_text_font=”” fusion_font_variant_text_font=”” font_size=”” line_height=”” letter_spacing=”” text_transform=”” text_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=””]很多人對對羥基苯甲酸酯(paraben) 這只防腐劑都不會感到陌生,坊間很多說法,指出這只防腐劑可能會與女士患上乳癌有關,讓我在這裡先作一個簡單的解釋。

什麼是對羥基苯甲酸酯?

對羥基苯甲酸酯是一種常用在化妝品、護膚品、食物或藥物內的防腐劑。

常見的paraben種類有7種,

  • 對羥基苯甲酸甲酯(Methyl paraben)
  • 對羥基苯甲酸乙酯(Ethyl paraben)
  • 對羥基苯甲酸丙酯(Propyl paraben)
  • 對羥基苯甲酸丁酯(Butyl paraben)
  • 對羥基苯甲酸異丙酯(Isopropyl paraben)
  • 對羥基苯甲酸異丁酯(Isobutyl paraben)對羥基苯甲酸苯甲酯 (benzyl paraben)

早在2014年,歐盟禁止了於化妝品內使用5種paraben (Isopropylparaben, Isobutylparaben, Phenylparaben, Benzylparaben and Pentylparaben)。

那麼paraben究竟是抗菌的好幫手,還是可以致癌的兇手?

事源於2004 年,英國一名細胞分子生物學家Dr. Philippa Darbre 在一本毒理學的期刊(Journal of Applied Toxicology) 上發表一篇論文,她在20個人類乳房腫瘤的樣本里,發現paraben的平均濃度為20.6ng/g 。

而於2012年,Dr. Philippa Darbre於40個2005至2008年間,被確診乳癌而需要切除乳房的病人當中,抽取160個樣本,當中99%發現含有最少一種paraben, 而其中60%更含有五種。

近至2022年,美國內分泌學會的年度會議上發表了一份新的研究報告,有三個發現:
Parabens 加速黑人乳癌細胞株的生長,在同一個濃度下,白人的乳癌細胞株則沒有加速生長。
Parabens 亦發現增加黑人和白人的乳癌細胞株中激素作用的基因表達。
Parabens 會加速乳癌細胞的擴散,其影響在黑人乳癌細胞株中比較大。

到現時為止,醫學界仍未有確切研究證明日常生活中吸取的parabens總濃度會否導致乳癌。但這些研究也提高了我們對生活中常用的防腐劑的警覺性。[/fusion_text][/fusion_builder_column][fusion_builder_column type=”1_3″ layout=”1_3″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” spacing=”” center_content=”no” column_tag=”div” link=”” target=”_self” link_description=”” min_height=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” type_medium=”” type_small=”” order_medium=”0″ order_small=”0″ dimension_spacing_medium=”” dimension_spacing_small=”” dimension_spacing=”” dimension_margin_medium=”” dimension_margin_small=”” margin_top=”” margin_bottom=”” padding_medium=”” padding_small=”” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” hover_type=”none” border_sizes=”” border_color=”” border_style=”solid” border_radius=”” box_shadow=”no” dimension_box_shadow=”” box_shadow_blur=”0″ box_shadow_spread=”0″ box_shadow_color=”” box_shadow_style=”” z_index_subgroup=”regular” z_index=”” z_index_hover=”” overflow=”” background_type=”single” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”” background_image=”” background_image_id=”” lazy_load=”none” skip_lazy_load=”” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” render_logics=”” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_offset=”” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ transform_type=”regular” transform_scale_x=”1″ transform_scale_y=”1″ transform_translate_x=”0″ transform_translate_y=”0″ transform_rotate=”0″ transform_skew_x=”0″ transform_skew_y=”0″ transform_scale_x_hover=”1″ transform_scale_y_hover=”1″ transform_translate_x_hover=”0″ transform_translate_y_hover=”0″ transform_rotate_hover=”0″ transform_skew_x_hover=”0″ transform_skew_y_hover=”0″ transform_origin=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” last=”false” border_position=”all” first=”true” spacing_right=””][fusion_text columns=”” column_min_width=”” column_spacing=”” rule_style=”” rule_size=”” rule_color=”” hue=”” saturation=”” lightness=”” alpha=”” content_alignment_medium=”” content_alignment_small=”” content_alignment=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” margin_top=”” margin_right=”” margin_bottom=”” margin_left=”” fusion_font_family_text_font=”” fusion_font_variant_text_font=”” font_size=”” line_height=”” letter_spacing=”” text_transform=”” text_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=””]

參考資料:

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https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=uriserv:OJ.L_.2014.107.01.0005.01.ENG

https://pubmed.ncbi.nlm.nih.gov/14745841/

https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jat.1786

https://www.endocrine.org/news-and-advocacy/news-room/2022/chemicals-in-personal-care-products-cause-harmful-effects-in-breast-cancer-cells-from-black-women

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